The Sheriff's Office responded to a report of possible cardiac arrest at Davis' home around 9:30 p.m. on Monday night. She was transferred to a local hospital, where she died around 10:28 p.m.
The Sheriff's Coroners Office will investigate the exact cause and manner of Davis' death, the Sheriff's Office said.
She was the subject of Tupac's iconic 1995 hit "Dear Mama."
Tupac was famously shot on Sept. 7, 1996 in Las Vegas, Nevada. After six days in the hospital, the then-25-year-old succumbed to his injuries. The shooter was never caught.
Following her son's death, Davis founded the Tupac Amaru Shakur Foundation, and later helped create Broadway musical Holler If Ya Hear Me in 2014, which featured the rapper's music. She also served as the CEO of Amaru Entertainment, Inc., a record and film production company she founded in Atlanta.
In her youth, Davis – who was born in North Carolina – was an activist and Black Panther.
Earlier this year, she was embroiled in a divorce battle with Gust Davis, her husband of 12 years, TMZ reported. Davis filed legal documents in March asking a North Carolina judge to prevent the minister from receiving alimony from Tupac's estate, which TMZ said generates around $900,000 a year.